What is St. John's Wort?

St. John's Wort is a flowering plant belonging to the Hypericaceae family, commonly found in Europe, North America, and parts of Asia. Traditionally used in herbal medicine, the plant is most recognized for its potential effects on mental health, particularly for mild to moderate depression. Several studies suggest that St. John's Wort may influence neurotransmitter levels in the brain, similar to some conventional antidepressants, by inhibiting the reuptake of serotonin, dopamine, and norepinep

How many studies on St. John's Wort are available?

NutriVouch references 207 human studies on St. John's Wort, all peer-reviewed and indexed on PubMed.

Is St. John's Wort effective for Depression Support?

For Depression Support, St. John's Wort has an effectiveness score of 8/10 — strong evidence supporting clinical use. Based on 31 relevant studies.

Is St. John's Wort effective for Stress Relief?

For Stress Relief, St. John's Wort has an effectiveness score of 4/10 — weak or limited clinical evidence. Based on 9 relevant studies.

Is St. John's Wort effective for Anxiety Support?

For Anxiety Support, St. John's Wort has an effectiveness score of 4/10 — weak or limited clinical evidence. Based on 11 relevant studies.

Is St. John's Wort effective for Better Sleep?

For Better Sleep, St. John's Wort has an effectiveness score of 3/10 — weak or limited clinical evidence. Based on 5 relevant studies.

Is St. John's Wort effective for Anti-Inflammation?

For Anti-Inflammation, St. John's Wort has an effectiveness score of 3/10 — weak or limited clinical evidence. Based on 11 relevant studies.

Confidence level

Strong evidence

207 studies

St. John's Wort

Absorption

✦Take with food to enhance absorption and reduce stomach upset. Avoid taking with other medications as it can interact and affect their efficacy.

Daily Dose

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Common dose: 300–900 mg of extract per day, standardized to 0.3% hypericin, divided into 2-3 doses

RDA: No official RDA established

Upper limit: Not established

Best form: Standardized extract with 0.3% hypericin or 2-5% hyperforin

Timing: Take with meals to reduce potential gastrointestinal upset.

St. John's Wort can interact with many medications, including antidepressants and contraceptives. Consult a healthcare provider before use, especially if taking other medications.

Effects