Stress Relief

Supplements studied for reducing psychological stress and modulating the stress response. This includes adaptogens — substances that help the body adapt to stressors by regulating the hypothalamic-pituitary-adrenal (HPA) axis and cortisol levels. Research focuses on reduction of perceived stress (PSS scores), anxiety symptoms, and salivary/serum cortisol as objective biomarkers. Popular adaptogenic herbs here include Ashwagandha, Rhodiola Rosea, and Panax Ginseng.

60 supplements have studies linked to this goal. Ashwagandha scores highest (7/10), followed by L-Theanine (6/10) and Magnesium (6/10). 6 of them reach moderate or strong support — the rest are thinly studied or showed little effect.

Supplements rated for Stress Relief

How to read these scores

The 0–10 score reflects how well the evidence supports a supplement for this specific goal, independent of how much it has been studied overall. It is an editorial rating checked against meta-analyses — how we set it.