What is Vitamin B12 (Cobalamin)?

Vitamin B12, also known as cobalamin, is a water-soluble vitamin that plays a critical role in various bodily functions. Naturally found in animal products like meat, fish, dairy, and eggs, it is essential for DNA synthesis, red blood cell formation, and neurological function. Research has explored its impact on general health, particularly its role in preventing anemia and supporting cognitive health. Studies indicate that adequate levels of vitamin B12 are crucial for maintaining energy levels

How many studies on Vitamin B12 (Cobalamin) are available?

NutriVouch references 121 human studies on Vitamin B12 (Cobalamin), all peer-reviewed and indexed on PubMed.

Is Vitamin B12 (Cobalamin) effective for Energy Levels?

For Energy Levels, Vitamin B12 (Cobalamin) has an effectiveness score of 6/10 — moderate evidence — works in some populations. Based on 21 relevant studies.

Is Vitamin B12 (Cobalamin) effective for Mood Support?

For Mood Support, Vitamin B12 (Cobalamin) has an effectiveness score of 5/10 — moderate evidence — works in some populations. Based on 10 relevant studies.

Is Vitamin B12 (Cobalamin) effective for Depression Support?

For Depression Support, Vitamin B12 (Cobalamin) has an effectiveness score of 5/10 — moderate evidence — works in some populations. Based on 25 relevant studies.

Is Vitamin B12 (Cobalamin) effective for Exercise Performance?

For Exercise Performance, Vitamin B12 (Cobalamin) has an effectiveness score of 3/10 — weak or limited clinical evidence. Based on 6 relevant studies.

Is Vitamin B12 (Cobalamin) effective for Endurance?

For Endurance, Vitamin B12 (Cobalamin) has an effectiveness score of 3/10 — weak or limited clinical evidence. Based on 5 relevant studies.

Confidence level

Moderate evidence

121 studies

Vitamin B12 (Cobalamin)

Absorption

✦Best absorbed on an empty stomach with water. Sublingual forms bypass the digestive tract and may offer better absorption for some individuals.

Daily Dose

⚖

Common dose: 500–1,000 mcg daily

RDA: 2.4 mcg

Upper limit: Not established

Best form: Methylcobalamin and cyanocobalamin

Timing: With or without food, preferably at the same time each day.

Deficiency is more common in vegetarians and older adults. High doses are generally safe but consult a healthcare provider for specific health conditions.

Effects

🏃 Exercise Performance

3.06 studies›

🚴 Endurance

3.05 studies›

Food Sources

Clams98.9mcg per 100g
Liver (beef)83.1mcg per 100g
Trout5.4mcg per 100g
Salmon3.2mcg per 100g
Tuna2.5mcg per 100g