What is L-Citrulline?

L-Citrulline is a non-essential amino acid found naturally in watermelon. It is converted to L-arginine in the kidneys, which then serves as a precursor for nitric oxide production. Research focuses on its effects on blood pressure, arterial stiffness, and exercise performance.

How many studies on L-Citrulline are available?

NutriVouch references 181 human studies on L-Citrulline, all peer-reviewed and indexed on PubMed.

Is L-Citrulline effective for Exercise Performance?

For Exercise Performance, L-Citrulline has an effectiveness score of 6/10 — moderate evidence — works in some populations. Based on 41 relevant studies.

Is L-Citrulline effective for Muscle Recovery?

For Muscle Recovery, L-Citrulline has an effectiveness score of 5/10 — moderate evidence — works in some populations. Based on 25 relevant studies.

Is L-Citrulline effective for Endurance?

For Endurance, L-Citrulline has an effectiveness score of 5/10 — moderate evidence — works in some populations. Based on 12 relevant studies.

Is L-Citrulline effective for Circulation?

For Circulation, L-Citrulline has an effectiveness score of 5/10 — moderate evidence — works in some populations. Based on 27 relevant studies.

Is L-Citrulline effective for Blood Pressure?

For Blood Pressure, L-Citrulline has an effectiveness score of 4/10 — weak or limited clinical evidence. Based on 28 relevant studies.

Confidence level

Moderate evidence

181 studies

L-Citrulline

Last reviewed: 4/3/2026

How to take L-Citrulline

✦Take on an empty stomach or with a light meal. L-Citrulline is more effective than L-arginine for raising plasma arginine levels because it bypasses first-pass metabolism. Split into 2 doses for sustained effect.