NutriVouch
Confidence level
Emerging evidence
172 studies

Spermidine

Last reviewed: 4/3/2026

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Absorption
Spermidine is well absorbed orally from food sources. Wheat germ extract is the most studied supplemental form. Take with meals.
Daily Dose
Common dose: 1-6 mg/day from supplements; average dietary intake ~7-12 mg/day
RDA: No established RDA
Upper limit: No established upper limit
Best form: Wheat germ extract
Timing: With meals
Bruneck Study: top third of dietary intake (~12 mg/day) associated with reduced mortality equivalent to 5.7 years younger.
Food Sources
  • Wheat germ~24.3 mg per 100g
  • Aged cheddar cheese~20 mg per 100g
  • Soybeans~12.8 mg per 100g
  • Mushrooms~8.8 mg per 100g

Not medical advice