Absorption
✦Fisetin has poor water solubility and low oral bioavailability. Taking with a fat source may improve absorption. Intermittent high-dose protocols (rather than daily low doses) are used in clinical trials.
Daily Dose
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Common dose: 100-500 mg/day
RDA: No established RDA
Upper limit: No established; up to 500 mg/day for one week tolerated
Best form: Fisetin powder in capsules; lipid-based formulations may improve absorption
Timing: With a fat-containing meal; senolytic protocols use intermittent dosing
Human evidence very limited. Only pilot study (n=10) showed mixed results. Average dietary intake ~0.4 mg/day.
Effects
Food Sources
- Strawberries~160 ug/g (~57 mg per pint)
- Apples~27 ug/g (~8 mg per large apple)
- Persimmons~10.5 ug/g (~2 mg per fruit)
- Grapes~3.9 ug/g (~1 mg per cup)