Fisetin is a naturally occurring flavonoid found in strawberries and other fruits that has demonstrated potent senolytic activity, selectively clearing senescent cells. Among 10 flavonoids tested in preclinical models, fisetin was the most effective senolytic. Late-life administration extended lifespan in mice, though human clinical data remains limited.

How many studies on Fisetin are available?

NutriVouch references 89 human studies on Fisetin, all peer-reviewed and indexed on PubMed.

Is Fisetin effective for Antioxidant Protection?

For Antioxidant Protection, Fisetin has an effectiveness score of 5/10 — moderate evidence — works in some populations. Based on 23 relevant studies.

Is Fisetin effective for Anti-Inflammation?

For Anti-Inflammation, Fisetin has an effectiveness score of 4/10 — weak or limited clinical evidence. Based on 15 relevant studies.

Is Fisetin effective for Anti-Aging?

For Anti-Aging, Fisetin has an effectiveness score of 4/10 — weak or limited clinical evidence. Based on 17 relevant studies.

Is Fisetin effective for Longevity?

For Longevity, Fisetin has an effectiveness score of 4/10 — weak or limited clinical evidence. Based on 6 relevant studies.

Is Fisetin effective for Cognitive Function?

For Cognitive Function, Fisetin has an effectiveness score of 3/10 — weak or limited clinical evidence. Based on 5 relevant studies.

Confidence level

Moderate evidence

89 studies

Fisetin

Last reviewed: 4/3/2026

How to take Fisetin

✦Fisetin has poor water solubility and low oral bioavailability. Taking with a fat source may improve absorption. Intermittent high-dose protocols (rather than daily low doses) are used in clinical trials.