Spermidine supplements improve memory in older adults
Mostly falseThe Claim
Spermidine is marketed as a brain-protecting longevity nutrient that sharpens memory and slows cognitive decline with age.
Origin
Animal studies showing autophagy-driven brain benefits and a small early pilot trial were widely promoted by spermidine supplement brands.
What Science Says
The 12-month SmartAge randomized trial (100 adults aged 60–90 with subjective cognitive decline) found no significant difference between spermidine (0.9 mg/day from wheat germ) and placebo in memory performance (between-group difference −0.03; 95% CI −0.11 to 0.05) or secondary outcomes. Only exploratory analyses hinted at possible effects on verbal memory and inflammation, which remain unconfirmed.
Verdict
Mostly False