DHEA is safe for long-term use
5.0Limited
evidence
evidence
The Claim
Some people believe that because DHEA is a naturally occurring hormone, it is safe to take over a long period without adverse effects.
Origin
This misconception is fueled by the perception that natural supplements are inherently safe, along with limited short-term studies showing few side effects.
What Science Says
Long-term safety data for DHEA is limited. Some studies suggest potential side effects, such as hormonal imbalances and increased risk of hormone-sensitive cancers, especially with prolonged use. A 2016 systematic review highlighted these concerns, recommending caution with long-term supplementation.
Verdict
Misleading
Sources
- PMID:32852449 The 2020 genitourinary syndrome of menopause position statement of The North American Menopause Society.
- PMID:39250810 Hormonal Treatments and Vaginal Moisturizers for Genitourinary Syndrome of Menopause : A Systematic Review.
- PMID:35744033 New Innovations for the Treatment of Vulvovaginal Atrophy: An Up-to-Date Review.