Vitamin B6 supplementation prevents heart disease
9.0Strong
evidence
evidence
The Claim
Some people believe that taking Vitamin B6 supplements can prevent or reduce the risk of heart disease due to its role in lowering homocysteine levels.
Origin
This belief originated from early observational studies that linked high homocysteine levels to heart disease and the role of B vitamins in metabolizing homocysteine.
What Science Says
While Vitamin B6 can reduce homocysteine levels, meta-analyses and large-scale RCTs have shown that this does not translate into a reduced risk of cardiovascular events. The effect size of homocysteine reduction is not sufficient to impact heart disease outcomes significantly.
Verdict
Misleading
Sources
- PMID:41615824 Combined B-vitamin supplementation on homocysteine and vascular outcomes in coronary heart disease: a meta-analysis.
- PMID:26420127 [Meta-analysis of clinical trials of folic acid, vitamin B12 and B6 supplementation on plasma homocysteine level and risk of cardiovascular disease].
- PMID:18412997 Homocysteine, B-vitamins and CVD.