Berberine has no side effects because it's natural
9.0Strong
evidence
evidence
The Claim
Many people believe that because berberine is natural, it does not have any side effects and is completely safe to use at any dosage.
Origin
This myth is perpetuated by the general assumption that natural substances are inherently safer than synthetic drugs.
What Science Says
Research shows that while berberine is generally well-tolerated, it can cause gastrointestinal issues such as diarrhea, constipation, and stomach cramps. Some studies have also suggested potential interactions with medications like metformin. Its safety profile requires careful consideration, especially in high doses or long-term use.
Verdict
False
Sources
- PMID:40763599 Multiple target and regulatory pathways of berberine.
- PMID:39141022 Effects of Berberis vulgaris, and its active constituent berberine on cytochrome P450: a review.
- PMID:39998703 The efficacy and safety of berberine in combination with cinnamon supplementation in patients with type 2 diabetes: a randomized clinical trial.