5-HTP is a natural antidepressant
evidence
The Claim
Many people believe that 5-HTP, a precursor to serotonin, can effectively treat depression as it increases serotonin levels in the brain. This belief is based on the idea that since antidepressants work by influencing serotonin, 5-HTP should naturally do the same.
Origin
This myth likely originates from early studies and the marketing efforts of supplement companies that focus on serotonin's role in mood regulation.
What Science Says
Research including randomized controlled trials (RCTs) indicates that while 5-HTP may have some potential benefits for mild depression, it is not as effective as standard antidepressant medications. A systematic review found that 5-HTP had a moderate effect size but the studies were small and often methodologically flawed. Current evidence is insufficient to recommend 5-HTP as a standalone treatment for depression.
Verdict
Partially True
Sources
- PMID:16023217 Serotonin a la carte: supplementation with the serotonin precursor 5-hydroxytryptophan.
- PMID:35940251 Effect of 5-Hydroxytryptophan on Fatigue in Quiescent Inflammatory Bowel Disease: A Randomized Controlled Trial.
- PMID:40944161 The Impact of 5-Hydroxytryptophan Supplementation on Cognitive Function and Mood in Singapore Older Adults: A Randomized Controlled Trial.