5-HTP helps with weight loss
4.0Limited
evidence
evidence
The Claim
There is a belief that 5-HTP can aid in weight loss by reducing appetite and cravings, as increased serotonin levels are associated with mood regulation and satiety.
Origin
This myth is fueled by anecdotal reports and some early studies that suggested appetite suppression as a side effect of higher serotonin levels.
What Science Says
While there are some small-scale studies suggesting that 5-HTP might reduce appetite, the overall evidence is limited and inconsistent. A meta-analysis has shown only modest appetite reduction and no significant weight loss. Larger, more rigorous studies are needed to establish any substantial effects on weight management.
Verdict
Misleading
Sources
- PMID:31780943 The Triple Combination Phentermine Plus 5-HTP/Carbidopa Leads to Greater Weight Loss, With Fewer Psychomotor Side Effects Than Each Drug Alone.
- PMID:38656972 Tesofensine, a novel antiobesity drug, silences GABAergic hypothalamic neurons.
- PMID:28127513 Preliminary fMRI findings concerning the influence of 5-HTP on food selection.